- この会議は香川医科大学第3内科 西岡幹夫教授がKrawitt教授（Vermont)やWiesner教授（Mayo)らと自己免疫性肝疾患に関する本を出版する際にハワイでミーティングをもたれ、その際に日米の研究者に集まってもらって小さな会をやろうということで始まりました。それが、1997年の6月のことです。今年は第2回にあたり、もう少し規模を大きくして行われることになりました。場所は今回も第1回に引き続きハワイのオアフ島ノースショアにあるTurtle Bay Hiltonです。
- 日本からは戸田剛太郎教授、井上恭一教授、大西三朗教授も参加され、アメリカからはGershwin教授（カルフォルニア大学デイビス校）、Krawitt教授、Wiesner教授、Tsai教授（ハワイ大学）らが参加され、全部で約30人が参加しました。
- 演題はAutoimmune hepatitis, Primary sclerosing cholangitis, Primary biliary cirrhosisに関してのもので、それぞれレベルの高い内容でした。
- 特別講演はRussell H. Wiesner: "Primary sclerosing cholangitis and its reccurrence following liver transplantation.", ME Gershwin: "Molecular and mechanistics considerations of primary biliary cirrhosis."が行われました。
- 特別企画として"Progress in the study of autoimmune hepatitis (AIH)."に関して西岡教授とKrawitt教授が話した後、若い先生方が”Diagnostic criteria of autoimmune hepatitis."について何人か発表し、戸田教授が全部をまとめて話をするというセッションが行われました。新しい診断基準を提案するところまではいきませんでしたが、今のAIHの診断基準についてみんながどう思っているのか率直な考えが披露されました。
- すべて、非常に和やかな雰囲気の中で、自由にディスカッションが行われ、みんな言いたいことを言うというどちらかというとアメリカンスタイルで進行し、とても実り多い会議となりました。Tsai教授もみんなの英語のレベルが非常に高いといっていました。Closing RemarksでKrawitt教授がSuccessfulだったといってくれた時は事務局を担当したものとしてほっと胸をなで下ろしました。参加された皆さんにこの場を借りて感謝したいと思います。
The Second US-Japan Meeting on Autoimmune Liver Diseases
Date: September 7 and 8, 1998
Meeting: Maui/Molokai
Reception: Kauai/Lanai
Place: Turtle Bay Hilton, P.O.Box 187, Kahuku, Hawaii, 96731, U.S.A.
Tel: 808-293-8811, Fax: 808-293-9147
Program:
September 7
13:25 - 13:30
Opening remarks: Mikio Nishioka
Part I Autoimmune hepatitis (Commentator E.L.Krawitt and N. Tsai)
Chairperson (1,2): Mikio Zeniya (Tokyo)
1. 13:30 - 13:45
Autoimmune features in chronic hepatitis C.
Toru Takahashi, Takafumi Ichida and Hitoshi Asakura
Third Department of Internal Medicine, Niigata University School of
Medicine, Asahimachidori-1, Niigata, Niigata, 951-8122, Japan
2. 13:45 - 14:00
Multivariate analysis of histological difference between autoimmune
hepatitis and chronic hepatitis C.
Toshio Morizane1, Toshikazu Uchida2, Minoru Shibata3, Satoshi Tsunematsu1,
Yasutaka Inagaki4, Kazuhiko Sekiyama5, Shouichirou Takahashi6, Naoki Kumagai7,
Kanji Tsuchimoto, Yasushi Onozuka8, Makoto Yoshiba5, Yukihisa Ueno8, and
Keiji Mitamura3.
1Department of Medicine, Kanagawa Dental College, 2Department of Pathology,
Nihon University School of Medicine, 3Second Department of Internal Medicine,
Showa University School of Medicine, 4Department of Internal Medicine,
Nihon Koukan Hospital, 5Department of Internal Medicine, Fujigaoka Hospital,
Showa University, 6Department of Internal Medicine, Fujiyoshida City Hospital,
7Department of Internal Medicine, Kitasato Laboratory Hospital, 8Department
of Internal Medicine, Kawasaki Chuo Hospital.
Chairperson (3, 4): Toshio Morizane (Kanagawa)
3. 14:00 - 14:15
Anti-liver-specific-idiotype-bering antibody (anti-LSIA) detected
by H2 monoclonal antibody Fab portion in autoimmune hepatitis and other
chronic liver diseases.
Satoshi Tsunematsu1, Minoru Shibata2, Reiko Sato, and Toshio Morizane1
1Depertment of Medicine, Kanagawa Dental College, Kanagawa, Japan;
2Second Department of Internal Medicine, Showa University School of Medicine,
Tokyo, Japan
4. 14:15 - 14:30
Alteration of TCR Vβ repertoire of liver infiltrating T cell after
corticosteroid treatment in autoimmune hepatitis.
Mikio Zeniya, Akira Kuramoto, Hiroki Takahashi, Yoshio Aizawa, and
Gotaro Toda.
Department of Internal Medicine (I), The JIKEI University School of
Medicine, Tokyo, Japan.
Coffee break 14:30 - 14:45
Special session
Chairperson of special session: Gotaro Toda (Tokyo)
14:45 - 16:45 Special Session
a) Progress in the study of autoimmune hepatitis (AIH).
Mikio Nishioka1 and Edward L Krawitt2
1Third Department of Internal Medicine, Kagawa Medical University.
2Gastroenterology unit, University of Vermont.
Issue 1: AIH in Japan and US: genetic background is different?
1) Incidence of AIH in comparison with viral hepatitis.
2) HLA phenotypes.
Issue 2: Clinical significance of anti-LKM1 and anti-SLA
Issue 3: Prognosis of AIH.
b) Proposal of new diagnositc criteria for autoimmune hepatitis.
Mikio Zeniya, Takafumi Ichida, Saburo Onishi, Morikazu Onji, Hiroshi Miyakawa, Toshio Ito, Toshio Morizane, Mikio Nishioka, and Gotaro Toda..
1) International diagnostic criteria: how to improve specificity and
sensitivity?:
2) Problems with the current criteria.
3) Acute-onset AIH.
4) Histology of the liver: how different?
5) Variables to differentiate AIH from other liver diseases: multivariate
analysis.
16:45 - 17:00
Summary of the special session about autoimmune hepatitis.
Gotaro Toda
Department of Internal Medicine (I), The JIKEI University School of
Medicine, Tokyo, Japan.
Reception
18:30 - 20:30
(with casual wears)
September 8
Part II. Primary sclerosing cholangitis
Chairperson (5) : Shotaro Sakisaka (Fukuoka)
5. 8:00 - 8:15
Characteristics of PSC and unclassified colitis as a complication.
Tomohiro Ogi, Asahiro Morishita, N. Uchida, and Mikio Nishioka.
Third Department of Internal Medicine, Kagawa Medical University.
Chairperson of special lecture 1: Mikio Nishioka (Kagawa)
8:15 - 9:15
Special Lecture 1
Primary sclerosing cholangitis and its reccurrence following liver
transplantation.
Russell H. Wiesner
Mayo Clinic, USA.
Part III. Primary Biliary Cirrhosis (Commentator: Eric M. Gershwin and Russell H. Wiesner)
Chairperson (6, 7): Takafumi Ichida (Niigata)
6. 9:15 - 9:30
Retrospective analysis of 35 patients with primary biliary cirrhosis.
Toshio Ito, Shingo Kinoyama, Tetsuya Kimura, Gouichi Niiyama, Toshiya
Onogi, Nobuhiro, Yoshida, Akiko Sho, Jun-ichi Uchida, Kensuke Goto, Atsushi
Sugahara, Ichiro Miyake, and Gotaro Yamada
Center of Liver Diseases, Kawasaki Hospital, Kawasaki Medical School,
Okayama, Japan
7. 9:30- 9:45
Clinical profile and prognosis of primary biliary cirrhosis in Japan
Kyoichi Inoue1, Junko Hirohara, Toshiaki Nakano, Seizaburou Arita2,
Kiyohiro Higuchi3, Masao Omata, Yasushi Shiratori4
Third Department of Internal Medicine, Kansai Medical University, Osaka,
Japan1,
Mathematics, Kansai Medical University, Osaka, Japan2,
Third Department of Internal Medicine, Toyama Medical and Pharmaceutical
University, Toyama, Japan3,
Second Department of Internal Medicine, Tokyo University, Tokyo, Japan4.
Chairperson (8, 9): Hiromi Ishibashi (Fukuoka)
8. 9:45 - 10:00
Beneficial effects of bezafibrate in PBC.
Shinji Iwasaki, Takashi Maeda, Saburo Onishi
Institute; First department of internal medicine, Kochi Medical School
9. 10:00 - 10:15
Treatment of symptomatic primary biliary cirrhosis with lymphocytapheresis
Takafumi Ichida, Kazunari Satoh, Moriaki Uchida, Satoru Yamagiwa, Kenji
Yonekura, Kazuhito Sugimura, Kiyoshi Ishihara, Hitoshi Asakura
Department of Internal Medicine III, Niigata University School of Medicine
10:15 - 10:30
Coffee break
Chairperson (10, 11): Hiroshi Miyakawa (Kanagawa)
10. 10:30 - 10:45
High frequency of reactivity with the lower molecular weight components
of 2-oxo-acid dehydrogenase complex in Japanese patients with primary biliary
cirrhosis and autoimmune cholangitis.
Katsuhisa Omagari, Hideki Kinoshita, Isao Matsuo, Nobuhiro Ikuno, Shigeru
Kohno
Second Department of Internal Medicine, Nagasaki University School
of Medicine, Nagasaki, Japan
11. 10:45 - 11:00
Different paracellular routes for bile regurgitation in primary
biliary cirrhosis and primary sclerosing cholangitis
Shotaro Sakisaka1, Takumi Kawaguchi1, Eitaro Taniguchi1, Hironori Koga1,
Kurumi Sasatomi1, Masaru Harada1, Michio Mori2, and Michio Sata1
1Second Department of Medicine, Kurume University School of Medicine,
and 2Department of Pathology, Sapporo Medical School, Japan.
Chairperson (12, 13): Katsuhisa Omagari (Nagasaki)
12. 11:00 - 11:15
The B cell and T cell epitopes of PDC-E2 and the role of lipoic
acid in immune response in PBC
Hiromi Ishibashi1, Kichiko Koike2, Shinji Shimoda, Hirohisa Shigematsu,
Yasunori Ichiki,Kazuhiro Hayashida, Minoru Nakamura1, Masahiko Koike2,
Yoshiyuki Niho1
1The First Department of Internal Medicine, Faculty of Medicine, Kyushu
University, Fukuoka 812-8582, Japan, 2the Department of Pathological
Biochemistry, Atomic Disease Institute, Nagasaki University School
of
Medicine, Nagasaki 852-8523, Japan
13. 11:15 - 11:30
Increased nitric oxide production by antigen presenting dendritic
cells is responsible for low allogenic mixed leukocyte reaction in primary
biliary cirrhosis.
Toshikazu Masumoto, SMF Akbar, Kazuhisa Yamamoto, Morikazu Onji.
3rd Department of Internal Medicine, Ehime University School of Medicine,
Ehime, Japan.
Chairperson (14, 15,16): Saburo Onishi (Kouchi)
14. 11:30 - 11:45
Detection of anti-gp210 antibodies in primary biliary cirrhosis
by an enzyme-linked immunosorbent assay using a synthesized polypeptide.
Minoru Shibata1, Kazuhiko Ouya2, Kiyomitsu Miyachi3, Tsuneyoshi Horigome4,
Yasushi Onozuka5, Yukihisa Ueno5, Toshio Morizane6, Keiji Mitamura1
1Second Department of Internal Medicine, Showa University School of
Medicine, 2Medical Biological Laboratories, 3Keigu Medical Clinic, 4Department
of Biochemistry, Faculty of Science, Niigata University, 5Department
of Medicine,Kawasaki Chuo Hospital, 6Department of Medicine, Kanagawa
Dental College
15. 11:45 - 12:00
Detection of anti-BCOADC-E2 antibody by ELISA using recombinant
fusion protein in anti-PDC-E2-negative PBC.
Hiroshi Miyakawa, Kazuhiro Abe, Eriko Kitazawa, Kentaro Kikuchi, Naomi
Kawaguchi, Hirotoshi Fujikawa, and Makoto Kako.
Fourth Department of Internal Medicine, Teikyo University School of
Medicine, Kanagawa, Japan.
16. 12:00 - 12:15
A novel antibody to 25 kda doublet/triplet proteins found in patients
with autoimmune hepatic diseases.
Kiyomitsu Miyachi, Saeko Takano, Hiroshi Matsushima, Raleigh W.Hankins1,
Tsuneyo Mimori, Toshifumi Azuma, Yasutaka Inagaki, Toshio Morizane, Masaya
Oda, Hiromasa Ishii, Yasuyoshi Kiryu2, Shouzou Matsushima, Tatsushi Komatsu3,
Etsuko Hashimoto, Naoaki Hayashi4.
1Health Science Research Institute, 2Department of Medicine, Keio University,
School of Medicine, 3Department of Gastroenterology, Yokohama National
Hospital
4Department of Gastroenterology, Tokyo Women’s Medical College.
12:15 - 13:00
Lunch
Chairperson of special lecture 2: Kyoichi Inoue (Osaka)
13:00 - 14:00
Special Lecture 2
Molecular and mechanistics considerations of primary biliary cirrhosis.
ME Gershwin, Division of Rheumatology, Allergy and Clinical Immunology,
University of California at Davis, Davis, CA, USA.
14:00 - 14:05
Closing remarks: Edward L Krawitt
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